{"id":9211,"date":"2022-04-19T11:44:28","date_gmt":"2022-04-19T09:44:28","guid":{"rendered":"https:\/\/www.ims-chips.de\/?p=9211"},"modified":"2022-04-26T13:05:11","modified_gmt":"2022-04-26T11:05:11","slug":"panamea-3","status":"publish","type":"post","link":"https:\/\/www.ims-chips.de\/?p=9211","title":{"rendered":"PanaMEA &#8211; ASIC f\u00fcr ein Miniatur-Pankreas-Implantat"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9211\" class=\"elementor elementor-9211\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f8be919 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"f8be919\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c0ea536 exad-glass-effect-no exad-sticky-section-no\" data-id=\"c0ea536\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-672976b exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"672976b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">IMS CHIPS Newsletter 1\/2022<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-49971e9 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"49971e9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-066e9d7 exad-glass-effect-no exad-sticky-section-no\" data-id=\"066e9d7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31d8acf exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"31d8acf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PanaMEA - ASIC f\u00fcr ein Miniatur-Pankreas-Implantat<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a7078b exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"4a7078b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Front-End-Signalverarbeitung der von einem Mikro-Elektroden-Array (MEA) <\/strong><strong>erfassten elektrischen Betazellenaktivit\u00e4ten<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c146d15 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"c146d15\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eddb049 exad-glass-effect-no exad-sticky-section-no\" data-id=\"eddb049\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cf9a4fc exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"cf9a4fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1385\" height=\"397\" src=\"https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF.jpg\" class=\"attachment-full size-full wp-image-9214\" alt=\"PanaMEA \u2013 ASIC f\u00fcr ein Miniatur-Pankreas-Implantat\" srcset=\"https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF.jpg 1385w, https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-300x86.jpg 300w, https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-1024x294.jpg 1024w, https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-768x220.jpg 768w\" sizes=\"(max-width: 1385px) 100vw, 1385px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-548a105 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"548a105\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Front-End Betazellen-Signalverarbeitungsschema<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dfa14c8 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"dfa14c8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7f0c6c7 exad-glass-effect-no exad-sticky-section-no\" data-id=\"7f0c6c7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a52b9e0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"a52b9e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Weltweit leiden Millionen von Menschen an\n  Diabetes mellitus Typ 2, das durch eine unzureichende\n  Insulinaussch\u00fcttung des K\u00f6rpers\n  verursacht wird. Das Insulin wird in den\n  Betazellen der Bauchspeicheldr\u00fcse gebildet.\n  Es besteht ein direkter Zusammenhang\n  zwischen der elektrischen Aktivit\u00e4t der\n  Betazelle in Form von Membran-Oszillationsst\u00f6\u00dfen\n  und der extrazellul\u00e4ren\n  Glukosekonzentration. Im BMBF-Projekt\n  \u201ePanaMEA\u201c (Pankreas-Implantat auf MEABasis,\n  F\u00f6rderkennzeichen 13GW0397)\n  wird ein miniaturisiertes Pankreas-Implantat\n  entwickelt, das diese elektrische Aktivit\u00e4t\n  misst.<\/p>\n<p>Die zentrale Aufgabe f\u00fcr das IMS ist die\nEntwicklung eines stromsparenden Front-\nEnd-ASICs zur Signalverarbeitung der\nvon einem Mikroelektroden-Array (MEA)\nerfassten Betazellensignale. F\u00fcr das Betazellensignal\nwird ein Biomarker, der\nso genannte Fraction of Plateau Phase\n(FOPP), definiert. Er ist der prozentuale\nAnteil an Zeit mit Betazellenaktivit\u00e4t. Ein\nhoher FOPP-Wert entspricht einem hohen\nGlukosespiegel.<\/p>\n<p>Bei herk\u00f6mmlichen\nBetazellen-\u00dcberwachungsmethoden werden\nalle Signaldetails, einschlie\u00dflich der FOPPirrelevanten\nhochfrequenten Anteile, aufgezeichnet\nund daraus der FOPP-Wert berechnet.\nDies f\u00fchrt zu einer gro\u00dfen Datenmenge\nund hat einen hohen Stromverbrauch f\u00fcr\ndie Daten\u00fcbertragung und -verarbeitung\nzur Folge. Anstatt alle hochfrequenten\nSignaldetails aufzuzeichnen, wird mit Hilfe\nvon Dioden und Kondensatoren ein differentieller\nH\u00fcllkurvendetektor realisiert, der die\nFOPP-relevanten Information bereitstellt. Der\nEntwicklungsaufwand wird auf ein Minimum\nreduziert und das Datenmenge stark verringert.\nDas Messkonzept und die Funktion\nder ASIC-Schaltungen wurden bereits\ndurch Messungen \u00fcberpr\u00fcft. Die n\u00e4chsten\nSchritte sind die Durchf\u00fchrung von In-vitro-\nMessungen und die Verkapselung des ASICs\nf\u00fcr Implantationsexperimente.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b1baa35 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"b1baa35\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f8b7cf4 exad-glass-effect-no exad-sticky-section-no\" data-id=\"f8b7cf4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e365f85 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"e365f85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Kontakt:<\/strong>\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-23ff211 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"23ff211\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-150bcf0 exad-glass-effect-no exad-sticky-section-no\" data-id=\"150bcf0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6fd8d0 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"a6fd8d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Zili Yu<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4cd6552 exad-glass-effect-no exad-sticky-section-no\" data-id=\"4cd6552\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b2715cb exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"b2715cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tel: +49 711 21855\u00a0 325<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-b5caf70 exad-glass-effect-no exad-sticky-section-no\" data-id=\"b5caf70\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c05301a exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"c05301a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"mailto:ziliyu@ims-chips.de\">ziliyu@ims-chips.de<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In dem vom BMBF gef\u00f6rderten Projekt wird am IMS ein ASIC f\u00fcr ein Miniatur-Pankreasimplantat entwickelt. Ein einzigartiges<br \/>\nMerkmal des Designs ist eine integrierte L\u00f6sung f\u00fcr die FOPP (Fraction of Plateau Phase)-Erkennung von Betazellenaktivit\u00e4ten.<br \/>\nDurch einen intelligenten Ansatz werden die Entwicklungskosten<br \/>\nauf ein Minimum reduziert; dadurch entsteht ein stromsparendes System, das f\u00fcr die hochentwickeltere \u00dcberwachung der Betazellenaktivit\u00e4t eingesetzt werden kann.<\/p>\n","protected":false},"author":1,"featured_media":9213,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[18],"class_list":["post-9211","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter-1-2022","tag-panamea"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PanaMEA - ASIC f\u00fcr ein Miniatur-Pankreas-Implantat - Institut f\u00fcr Mikroelektronik Stuttgart<\/title>\n<meta name=\"description\" content=\"ASIC f\u00fcr einMiniatur-Pankreas-Implantat\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ims-chips.de\/?p=9211\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PanaMEA - ASIC f\u00fcr ein Miniatur-Pankreas-Implantat - Institut f\u00fcr Mikroelektronik Stuttgart\" \/>\n<meta property=\"og:description\" content=\"ASIC f\u00fcr einMiniatur-Pankreas-Implantat\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ims-chips.de\/?p=9211\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Mikroelektronik Stuttgart\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-19T09:44:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-04-26T11:05:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ims-chips.de\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF_.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"634\" \/>\n\t<meta property=\"og:image:height\" content=\"514\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"meier\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Verfasst von\" \/>\n\t<meta name=\"twitter:data1\" content=\"meier\" \/>\n\t<meta name=\"twitter:label2\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data2\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ims-chips.de\\\/?p=9211#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ims-chips.de\\\/?p=9211\"},\"author\":{\"name\":\"meier\",\"@id\":\"https:\\\/\\\/www.ims-chips.de\\\/#\\\/schema\\\/person\\\/9839fb63530e7563aa83867413b8c6e7\"},\"headline\":\"PanaMEA &#8211; 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